The Lambert-Eaton Myasthenic Syndrome — an Overview
نویسندگان
چکیده
منابع مشابه
Lambert-Eaton myasthenic syndrome.
Lambert-Eaton myasthenic syndrome (LEMS) is an idiopathic or paraneoplastic syndrome producing antibodies against presynaptic voltage-gated P/Q calcium channels. This decreases calcium entry into the presynaptic terminal, which prevents binding of vesicles to the presynaptic membrane and acetylcholine release. LEMS is most often associated with small cell lung cancer, although idiopathic presen...
متن کاملLambert-Eaton myasthenic syndrome involving the diaphragm.
Inspiratory muscle function was assessed in a patient with the Lambert-Eaton myasthenic syndrome that developed in association with a bronchogenic carcinoma. Repetitive maximal inspiratory pressure measurements and the electromyographic response to phrenic nerve stimulation established involvement of the inspiratory muscles in general and the diaphragm specifically in this condition.
متن کاملClassic diseases revisited Lambert-Eaton myasthenic syndrome
The Lambert-Eaton myasthenic syndrome is a neuromuscular disorder characterised by defective neurotransmitter release at autonomic neurones and presynaptic terminals of the neuromuscular junction. It is caused by an IgG autoantibody formed against especially the P/Q type of voltagegated calcium channels (VGCC) which is an essential component of the mechanism of neurotransmitter release. Many pa...
متن کاملAn improved diagnostic assay for Lambert-Eaton myasthenic syndrome.
A new immunoprecipitation assay has been established for detecting antibodies to voltage-gated calcium channels (VGCCs) in Lambert-Eaton myasthenic syndrome (LEMS), using 125I-omega-conotoxin MVIIC, which binds to P-type VGCCs, to label extracts of human cerebellum. Fifty six of 66 serum samples (85%) from patients with clinically and electrophysiologically definite LEMS were positive for the p...
متن کاملAn autoimmune channelopathy associated with cancer: Lambert-Eaton myasthenic syndrome.
The Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that is often associated with lung cancer which shares a common antigenic protein with the motor nerve terminal. The myasthenic weakness is caused by an antibody-induced reduction in the release of acetylcholine from the nerve terminal. This study was undertaken to determine the target of LEMS antibodies and specify the volta...
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ژورنال
عنوان ژورنال: Neurology International Open
سال: 2018
ISSN: 2511-1795
DOI: 10.1055/s-0043-118274